FORT MYERS, Fla. -- After pitching had been the game's calling card for half of Sunday, a gigantic sixth inning for the Cardinals led them to a 10-3 win over the Red Sox at City of Palms Park.

Daisuke Matsuzaka, the Red Sox's fifth starter, and Kyle McClellan, the favorite to be the Cardinals' fifth starter, both put up zeros through the first five innings. These weren't run-of-the-mill Grapefruit League lineups, either. The Red Sox's batting order from Sunday could be identical to Opening Day's, and Albert Pujols and Matt Holliday made the cross-state trip for the Cardinals.

It was that duo who sparked a 10-run inning that saw 14 trips to the plate for St. Louis. All of those runs crossed the plate with two outs, and Pujols and Holliday drove in half of them.

After Matsuzaka retired the first two he faced in the sixth, Pujols walked in front of Holliday, who doubled to the gap in right-center. That was all for Matsuzaka, who was charged with two runs on three hits.

In a sign of his effectiveness, or at least the Cardinals' unfamiliarity with him, Matsuzaka struck out one batter looking in each of the first three innings. He finished with four strikeouts and two walks, and he's pitched well in two straight starts.

Andrew Miller came on for Matsuzaka, and he gave up two walks -- including one with the bases loaded -- four hits and six runs. Scott Atchison replaced Miller, issued a walk, and was burnt by Holliday and Pujols again. Both doubled, with Pujols' coming with the bases loaded.

McClellan allowed three hits and as many walks in five shutout innings while striking out two.

Nate Spears ripped a two-run double in the Red Sox's three-run eighth inning.

Up next for the Cardinals: The Cardinals are home in Jupiter on Monday and face the Nationals at 1:05 p.m. ET. Chris Carpenter is to make his third start of the spring after he allowed three runs in four innings his last time out on Wednesday against the Tigers.

Up next for the Red Sox: Jon Lester starts in Clearwater, Fla., on Monday against the Phillies. Dan Wheeler, Michael Bowden and Matt Albers are also to throw. First pitch is scheduled for 1:05 p.m on MLB.TV. On the Minor League side in Fort Myers, Jonathan Papelbon is scheduled to throw two innings, Daniel Bard will finish an inning and then pitch an additional inning and Bobby Jenks will throw one inning.