 |
Player | Position | Former Team | New Team | Transaction date | Notes | |
| 1. | Anderson, Brian | OF | BOS | KC | 12/23/09 | One-year contract | |
| 2. | Bailey, Jeff | OF | BOS | ARI | 12/28/09 | Minor League contract | |
| 3. | Beltre, Adrian | 3B | BOS | TEX | 1/05/11 | Six-year contract | |
| 4. | Byrd, Marlon | OF | BOS | NYM | 2/01/13 | Minor league contract | |
| 5. | Byrd, Paul | SP | BOS | --- | --- | --- | |
| 6. | Cash, Kevin | C | BOS | PHI | 11/19/10 | Minor league contract | |
| 7. | Crawford, Carl | OF | TB | BOS | 12/11/10 | Seven-year contract | |
| 8. | Gathright, Joey | OF | BOS | --- | --- | Minor league free agent | |
| 9. | Gomes, Jonny | DH | OAK | BOS | 12/01/12 | Two-year contract | |
| 10. | Hill, Rich | RP | BOS | CLE | 2/07/13 | Minor league contract | |
| 11. | Hoover, Paul | C | PHI | BOS | 1/26/11 | Minor league contract | |
| 12. | Jones, Hunter | RP | BOS | MIA | 11/05/09 | Traded with Minor Leaguer for Jeremy Hermida | |
| 13. | Kottaras, George | C | BOS | MIL | 11/18/09 | Claimed off waivers | |
| 14. | Lackey, John | SP | LAA | BOS | 12/16/09 | Agreed to five-year contract | |
| 15. | Lopez, Felipe | IF | BOS | TB | 2/02/11 | Minor league contract | |
| 16. | Martinez, Victor | C | BOS | DET | 11/26/10 | Four-year contract | |
| 17. | McCrory, Bob | RP | BAL | BOS | 11/24/09 | Minor League contract | |
| 18. | Moreno, Edwin | RP | SD | BOS | 1/15/10 | Minor League contract | |
| 19. | Nelson, Joe | RP | TB | BOS | 2/01/10 | Minor League contract | |
| 20. | Padilla, Vicente | RP | BOS | --- | 1/16/13 | Signed with the JPL Fukuoka SoftBank Hawks. | |
| 21. | Podsednik, Scott | OF | BOS | --- | --- | --- | |
| 22. | Ramirez, Ramon A. | RP | TB | BOS | 12/09/09 | Claimed off waivers | |
| 23. | Schoeneweis, Scott | RP | BOS | --- | --- | Released | |
| 24. | Shouse, Brian | RP | TB | BOS | 1/04/10 | Minor League contract | |
| 25. | Van Every, Jonathan | CF | BOS | WSH | 12/10/10 | Minor league contract | |
| 26. | Varitek, Jason | C | BOS | --- | 3/01/12 | Announced retirement | |
| 27. | Wagner, Billy | RP | BOS | ATL | 12/02/09 | One-year contract with club option | |
| 28. | Wakefield, Tim | SP | BOS | --- | 2/17/12 | Announced retirement | |
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