Teams 
| Name | Years Served | Record |
|---|---|---|
| Terry Francona | 2004-Present | 375-273; Won 2004 & 2007 World Series |
| Grady Little | 2002-2003 | 188-136 |
| Joe Kerrigan | 2001 | 17-26 |
| Jimy Williams | 1997-2001 | 414-352 |
| Kevin Kennedy | 1995-1996 | 171-135 |
| Butch Hobson | 1992-1994 | 207-232 |
| Joe Morgan | 1988-1991 | 301-262 |
| John McNamara | 1985-1988 | 297-273 |
| Ralph Houk | 1981-1984 | 312-282 |
| Don Zimmer | 1976-1980 | 411-304 |
| Darrell Johnson | 1974-1976 | 220-188 |
| Eddie Kasko | 1970-1973 | 345-295 |
| Eddie Popowski | 1969 | 6-4 |
| Dick Williams | 1967-1969 | 260-217 |
| Pete Runnels | 1966 | 8-8 |
| Billy Herman | 1964-1966 | 128-182 |
| Johnny Pesky | 1963-1964, 1980 | 147-179 |
| Billy Jurges | 1959-1960 | 59-63 |
| Del Baker | 1960 | 2-5 |
| Rudy York | 1959 | 0-1 |
| Pinky Higgins | 1955-1959, 1960-1962 | 560-556 |
| Lou Boudreau | 1952-1954 | 229-232 |
| Steve O'Neill | 1950-1951 | 150-99 |
| Joe McCarthy | 1948-1950 | 223-145 |
| Joe Cronin | 1935-1947 | 1,071-916 |
| Bucky Harris | 1934 | 76-76 |
| Marty McManus | 1932-1933 | 95-153 |
| Shano Collins | 1931-1932 | 73-134 |
| Heinie Wagner | 1930 | 52-102 |
| Lee Fohl | 1924-1926 | 160-299 |
| Frank Chance | 1923 | 61-91 |
| Hugh Duffy | 1921-1922 | 136-172 |
| Ed Barrow | 1918-1920 | 213-203 |
| Jack Barry | 1917 | 90-62 |
| Bill Carrigan | 1913-1916, 1927-1929 | 489-500 |
| Jake Stahl | 1912-1913 | 144-88 |
| Patsy Donovan | 1910-1911 | 159-147 |
| Fred Lake | 1908-1909 | 110-80 |
| Deacon McGuire | 1907-1908 | 98-123 |
| Bob Unglaub | 1907 | 9-20 |
| George Huff | 1907 | 2-6 |
| Chick Stahl | 1906 | 14-26 |
| Jimmy Collins | 1901-1906 | 455-376 |
